Osteoblast extracellular Ca2+-sensing receptor regulates bone development, mineralization, and turnover
نویسندگان
چکیده
منابع مشابه
L-amino acid sensing by the extracellular Ca2+-sensing receptor.
The extracellular calcium (Ca(2+)(o))-sensing receptor (CaR) recognizes and responds to (i.e., "senses") Ca(2+)(o) as its principal physiological ligand. In the present studies, we document that the CaR is activated not only by extracellular calcium ions but also by amino acids, establishing its capacity to sense nutrients of two totally different classes. l-Amino acids, especially aromatic ami...
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Assistant Professor of Surgery & Research Health Scientist, Harvard Medical School, Brigham and Women's Hospital and the VA Boston Healthcare System, West Roxbury VAMC, 1400 VFW Parkway room 2B111, West Roxbury MA 02132, USA. Tel.: 617-323-7700 ext 35902, Fax: 857-203-5592 E-mail: [email protected] Faithful control of systemic Ca homeostasis is crucial for life for most, if not all, m...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2011
ISSN: 0884-0431
DOI: 10.1002/jbmr.520